Kwaliteitsbewaking Klinische Geneesmiddelanalyse en Toxicologie

Concentration tests and controls.

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Concentration tests 2020

Components Unit Round 2020.1 Round 2020.2 Round 2020.3 Round 2020.4
Antiretrovirals I
Atazanavir mg/l 3,73 1,87
Darunavir mg/l  1,44 2,88
Dolutegravir mg/l  0,943 0,472
Elvitegravir mg/l  0,469  1,88
Lopinavir mg/l 0,934 3,9
Rilpivirine mg/l  0,101 0,152
Ritonavir mg/l  2,38 1,91
Saquinavir mg/l  0,483 0,966
Antiretrovirals II
Amprenavir mg/l 0,481 5,04
Efavirenz mg/l  2,84  5,96
Etravirine mg/l 0,407 0,205
Nevirapine mg/l 6,29  2,84
Raltegravir mg/l  7,78  3,91
Tipranavir mg/l  28,17  56,63

 

Concentration tests 2019

Components Unit Round 2019.1 Round 2019.2 Round 2019.3 Round 2019.4
Antiretrovirals I
Atazanavir mg/l 2,07 0,149 5,15 0,933
Darunavir mg/l 0,965  5,78  2,88 4,83
Dolutegravir mg/l 5,52 2,21  0,878  0,442
Elvitegravir mg/l 0,927  0,463  2,30 1,85
Lopinavir mg/l  0,895  1,79  3,71 7,46
Rilpivirine mg/l 0,201 0,401  0,299  0,100
Ritonavir mg/l  0,973  2,43  1,81  0,486
Saquinavir mg/l  4,18 2,09  0,498  3,13
Antiretrovirals II
Amprenavir mg/l 0,927 4,97 2,50 0,464
Efavirenz mg/l  6,07  2,02  4,07  1,01
Etravirine mg/l 0,511  0,256  0,154  0,205
Nevirapine mg/l  2,85  5,71  8,51  1,90
Raltegravir mg/l  4,05  0,486  0,979  5,07
Tipranavir mg/l  42,78 21,40  16,16  32,13

 

Concentration tests 2018

Components Unit Round 2018.1 Round 2018.2 Round 2018.3 Round 2018.4
Antiretrovirals I
Atazanavir mg/l  0,505  1,02  0,242 0,760
Darunavir mg/l  0,986  4,95  2,95  1,98
Dolutegravir mg/l  2,83  0,142  0,424  1,07
Elvitegrar mg/l  0,117  2,45  0,972  0,489
Lopinavir mg/l  8,22  2,06  0,738  3,09
Rilpivirine mg/l  0,156  0,440  0,097  0,039
Ritonavir mg/l  1,82  0,972  1,45  2,43
Saquinavir mg/l  1,46  2,94  0,730  0,147
Antiretrovirals II
Amprenavir mg/l  0,456 4,03 1,01 2,52
Efavirenz mg/l  0,982  6,96 4,18  0,780
Etravirine mg/l  0,123  0,183  0,367  0,244
Nevirapine mg/l  2,92  4,83  1,93  5,80
Raltegravir mg/l  0,0259  3,43  2,14  0,857
Tipranavir mg/l  110,1  72,82  36,42  45,51

 

Concentration tests 2017

Components Unit Round 2017.1 Round 2017.2 Round 2017.3 Round 2017.4
Antiretrovirals I
Atazanavir mg/l 1,91  0,459 4,77 0,306
Darunavir mg/l 3,00  2,11  2,40  0,843
Dolutegravir mg/l 0,0984  0,988  2,95 1,48
Elvitegrar mg/l 0,121 1,51  0,754 1,01
Lopinavir mg/l 1,05  7,56  2,64 3,78
Rilpivirine mg/l —  —  0,156  0,0313
Ritonavir mg/l 0,388  0,975  1,94 2,44
Saquinavir mg/l 2,91  0,0935  0,466  1,17
Antiretrovirals II
Amprenavir mg/l 0,398 3,92  0,998 3,00
Efavirenz mg/l 0,787  4,65  1,18 3,95
Etravirine mg/l 0,783  0,385  0,147  0,246
Nevirapine mg/l 7,46  2,20  1,87  5,62
Raltegravir mg/l 1,98  0,623  1,19  0,0596
Tipranavir mg/l 19,50  19,18  14,65  39,17

Concentration tests 2016

Components Unit Round 2016.1 Round 2016.2 Round 2016.3 Round 2016.4
Antiretrovirals I
Atazanavir mg/l  0,218  1,51 0,903 3,01
Darunavir mg/l 0,352 6,58 0  3,28
Lopinavir mg/l 10,11 0,968 2,41  0,482
Rilpivirine mg/l  0,0584 0,182 0,363  0,0348
Ritonavir mg/l 0,427 2,67 6,64  0,848
Saquinavir mg/l 0,0964 2,40 0,240  7,17
Antiretrovirals II
Amprenavir mg/l 0,241 0,239 0,400 4,82
Efavirenz mg/l 0,867 5,37 6,47  0,433
Etravirine mg/l  0,165 0,082 0,247  0,826
Nevirapine mg/l  7,06  1,64 4,69  0,494
Raltegravir mg/l 0  0,895 0  1,50
Tipranavir mg/l  16,03  54,91 27,92  10,01

Concentration tests 2015

Components Unit Round 2015.1 Round 2015.2 Round 2015.3 Round 2015.4
Antiretrovirals I
Atazanavir mg/l  1,75  0,215  0,426  0,430
Darunavir mg/l  4,47  0,858  0,530  1,07
Lopinavir mg/l  0,529  12,09  7,96  1,09
Rilpivirine mg/l  0,441  0,0408  1,05  0,109
Ritonavir mg/l  0,977  5,02  1,98  0,752
Saquinavir mg/l  0,0932  2,40  4,73  0,191
Antiretrovirals II
Amprenavir mg/l  5,65  0,793  0,221  2,83
Efavirenz mg/l  4,58  0,661  1,32  1,32
Etravirine mg/l  0,127  0,910  0,338  0,0848
Nevirapine mg/l  15,72  1,70  3,14  1,13
Raltegravir mg/l  0,0144  7,53  0,480  4,52
Tipranavir mg/l  27,66  13,87  58,77  69

Concentration control (matrix: liquid human serum)

Components Weighed-in value
Unit 2020 2019 2018 2017 2016 2015 2014
Antiretrovirals I
Atazanavir mg/l 1,04 0,917 1,05 0,985 0,994 0,982 0,953
Darunavir mg/l  4,84 5,13 4,92 4,96 4,51 5,03 4,81
Dolutegravir mg/l  1,41 1,47 1,47 1,53 – – –
Elvitegravir mg/l  1,05 1,03 1,02 1,04 – – –
Lopinavir mg/l  6,54 6,61 6,84 7,01  6,91 6,62 7,09
Nelfinavir mg/l – – – – – – 2,04
Rilpivirine mg/l  0,284 0,311 0,292 0,302  0,299 0,298 –
Ritonavir mg/l  5,00 4,84 5,04 5,02  4,93 4,95 5,05
Saquinavir mg/l  1,35 1,39 1,52 1,50 1,48 1,57 1,48
Antiretrovirals II
Amprenavir mg/l 1,95 1,90 2,08 2,06 1,97 1,93 2,01
Efavirenz mg/l  2,46 2,32 2,30 2,55  2,66 2,50 2,53
Etravirine mg/l  0,980 1,06 1,01 1,02 1,02 1,03 0,977
Nevirapine mg/l  4,09 3,88 3,99 3,87 3,85 4,02 4,00
Raltegravir mg/l  1,90 1,86 2,12 2,05 1,97 2,05 1,94
Tipranavir mg/l  15,26 14,73 15,03 15,16  14,76 15,72 14,81
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