Kwaliteitsbewaking Klinische Geneesmiddelanalyse en Toxicologie

Concentration tests and controls.

KKGT / Programma’s / Anti-epileptica / Concentration tests and controls

Concentration tests 2021

Components Unit Round 2021.1 Round 2021.2 Round 2021.3 Round 2021.4
Carbamazepine mg/l  2,37 7,08
10,11-epoxide-CB mg/l  0,393 2,35
Ethosuximide mg/l  80,60  40,21
Phenobarbital mg/l 33,85 25,33
Phenytoin mg/l  14,53  5,80
Lamotrigine mg/l  0,759  12,62
Levetiracetam mg/l  4,54  24,16
Monohydroxy-carbazepine mg/l 17,11  11,38
Valproic acid mg/l 40,32  80,46

 

Concentration tests 2020

Components Unit Round 2020.1 Round 2020.2 Round 2020.3 Round 2020.4
Carbamazepine mg/l  5,76  9,65 19,24 7.72
10,11-epoxide-CBZ mg/l  0,721 3,22 6,42  2,17
Ethosuximide mg/l  82,84 166,3  66,36 49,90
Phenobarbital mg/l 21,46 35,91 28,65  57,45
Phenytoin mg/l  37,37  18,76 14,97  11,26
Lamotrigine mg/l  12,97  4,34  8,66 26,05
Levetiracetam mg/l  14,59  43,96  21,92  7,33
Monohydroxy-carbazepine mg/l 48,70  14,67  24,38 29,34
Valproic acid mg/l 58,40 97,73 155,9  78,18

 

Concentration tests 2019

Components Unit Round 2019.1 Round 2019.2 Round 2019.3 Round 2019.4
Carbamazepine mg/l 10,06 2,52 7,51 6,28
10,11-epoxide-CBZ mg/l 4,08  0,327 2,44  1,63
Ethosuximide mg/l  49,64 99,40 24,72 74,34
Phenobarbital mg/l  12,09 28,81 19,11 38,30
Phenytoin mg/l  19,39  16,18 6,44  12,91
Lamotrigine mg/l  4,97  0,746  12,38  9,92
Levetiracetam mg/l  12,10  18,17  24,10 3,02
Monohydroxy-carbazepine mg/l  6,44 19,36 12,84  32,17
Valproic acid mg/l  44,56  29,74  73,98 59,32

 

Concentration tests 2018

Components Unit Round 2018.1 Round 2018.2 Round 2018.3 Round 2018.4
Carbamazepine mg/l 9,46  5,68 18,77  11,36
10,11-epoxide-CBZ mg/l  0,764  2,29  7,11  3,06
Ethosuximide mg/l 55,34  166,1  45,55  83,04
Phenobarbital mg/l  34,67  28,50  24,49  71,26
Phenytoin mg/l  36,02  18,02  14,65  10,63
Lamotrigine mg/l  27,45  13,73  2,90  9,15
Levetiracetam mg/l  8,67  43,35  17,19  11,56
Monohydroxy-carbazepine mg/l  28,59  14,30  66,17  23,84
Valproic acid mg/l  57,72  82,47  71,14  165,0

 

Concentration tests 2017

Components Unit Round 2017.1 Round 2017.2 Round 2017.3 Round 2017.4
Carbamazepine mg/l 6,42  2,57 10,29  7,71
10,11-epoxide-CBZ mg/l 1,85  0,444 2,78  3,71
Ethosuximide mg/l 101,0  80,79  25,52  40,47
Phenobarbital mg/l 22,94  38,22  30,65  15,31
Phenytoin mg/l 11,68  19,45  5,86  15,59
Lamotrigine mg/l 13,24  6,62  0.995  10,61
Levetiracetam mg/l 11,62  2,79  23,30  15,52
Monohydroxy-carbazepine mg/l 33,09  16,54  9,95  6,63
Valproic acid mg/l 61,30  76,60  46,08  30,70

Concentration tests 2016

Components Unit Round 2016.1 Round 2016.2 Round 2016.3 Round 2016.4
Carbamazepine mg/l  8,83  4,41  17,58  11,00
10,11-epoxide-CBZ mg/l  2,77  0,737  5,52  1,84
Ethosuximide mg/l  66,25  132,3  43,99  88,11
Phenobarbital mg/l  28,30  37,68  18,79  56,46
Phenytoin mg/l  11,36  37,80  18,85  15,10
Lamotrigine mg/l  10,65  4,25  12,73  25,50
Levetiracetam mg/l  36,61  18,28  7,29  14,61
Monohydroxy-carbazepine mg/l  11,07  55,26  27,56  22,08
Valproic acid mg/l  42,32  63,39  84,30  126,6

Concentration tests 2015

Components Unit Round 2015.1 Round 2015.2 Round 2015.3 Round 2015.4
Carbamazepine mg/l 10,06 6,04  3,02  7,99
10,11-epoxide-CBZ mg/l 3,68 0,413  1,47  2,92
Ethosuximide mg/l 58,98 73,76  88,38  29,29
Phenobarbital mg/l 23,88 14,34  28,63  37,95
Phenytoin mg/l 6,54 26,19  9,81  16,25
Lamotrigine mg/l 12,72 6,37  1,02  10,11
Levetiracetam mg/l 19,65 3,02  9,82  16,26
Monohydroxy-carbazepine mg/l 7,68 15,37  20,46  30,51
Valproic acid mg/l 88,29 35,33  52,92  70,15

Concentrations control (matrix: lyophilised human serum)

Components Weighed-in value
Unit 2021 2020 2019 2018 2017 2016 2015 2014
Carbamazepine mg/l  8,16  7,97 7,83 7,90 7,72 7,86 7,79 7,86
10,11-epoxide-CBZ mg/l 1,90 2,00 2,03  2,00 1,95 1,97 2,05 2,03
Ethosuximide mg/l 69,51 68,75 69,51  69,33 69,88 69,80 69,37 68,14
Phenobarbital mg/l 29,19 29,68 29,85  29,75 28,74 30,26 29,59 29,69
Phenytoin mg/l 15,04 15,51 15,09  15,04 14,63 14,84 15,20 15,11
Lamotrigine mg/l 7,86 8,08 7,73  7,64 7,96 7,59 7,88 7,85
Levetiractam mg/l 14,62 15,14 15,06  15,08 14,57 14,35 15,22 14,79
Monohydroxy-carbazepine mg/l 19,68 20,21 20,05  20,10 19,90 19,72 19,82 20,08
Valproic acid mg/l  69,53  72,70 69,33  68,86 69,13 67,87 66,81 67,04
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