Kwaliteitsbewaking Klinische Geneesmiddelanalyse en Toxicologie

Concentration tests and controls.

Concentration tests 2017

Components Unit Round 2017.1 Round 2017.2 Round 2017.3 Round 2017.4
Antiretrovirals I
Atazanavir mg/l 1,91
Darunavir mg/l 3,00
Dolutegravir mg/l 0,0984
Elvitegrar mg/l 0,121
Lopinavir mg/l 1,05
Rilpivirine mg/l 0,195
Ritonavir mg/l 0,388
Saquinavir mg/l 2,91
Antiretrovirals II
Amprenavir mg/l 0,398
Efavirenz mg/l 0,787
Etravirine mg/l 0,783
Nevirapine mg/l 7,46
Raltegravir mg/l 1,98
Tipranavir mg/l 19,50

Concentration tests 2016

Components Unit Round 2016.1 Round 2016.2 Round 2016.3 Round 2016.4
Antiretrovirals I
Atazanavir mg/l  0,218  1,51 0,903 3,01
Darunavir mg/l 0,352 6,58 0  3,28
Lopinavir mg/l 10,11 0,968 2,41  0,482
Rilpivirine mg/l  0,0584 0,182 0,363  0,0348
Ritonavir mg/l 0,427 2,67 6,64  0,848
Saquinavir mg/l 0,0964 2,40 0,240  7,17
Antiretrovirals II
Amprenavir mg/l 0,241 0,239 0,400 4,82
Efavirenz mg/l 0,867 5,37 6,47  0,433
Etravirine mg/l  0,165 0,082 0,247  0,826
Nevirapine mg/l  7,06  1,64 4,69  0,494
Raltegravir mg/l 0  0,895 0  1,50
Tipranavir mg/l  16,03  54,91 27,92  10,01

Concentration tests 2015

Components Unit Round 2015.1 Round 2015.2 Round 2015.3 Round 2015.4
Antiretrovirals I
Atazanavir mg/l  1,75  0,215  0,426  0,430
Darunavir mg/l  4,47  0,858  0,530  1,07
Lopinavir mg/l  0,529  12,09  7,96  1,09
Rilpivirine mg/l  0,441  0,0408  1,05  0,109
Ritonavir mg/l  0,977  5,02  1,98  0,752
Saquinavir mg/l  0,0932  2,40  4,73  0,191
Antiretrovirals II
Amprenavir mg/l  5,65  0,793  0,221  2,83
Efavirenz mg/l  4,58  0,661  1,32  1,32
Etravirine mg/l  0,127  0,910  0,338  0,0848
Nevirapine mg/l  15,72  1,70  3,14  1,13
Raltegravir mg/l  0,0144  7,53  0,480  4,52
Tipranavir mg/l  27,66  13,87  58,77  69

Concentration control (matrix: liquid human serum)

Components Weighed-in value
Unit 2017 2016 2015 2014
Antiretrovirals I
Atazanavir mg/l 0,985 0,994 0,982 0,953
Darunavir mg/l 4,96 4,51 5,03 4,81
Dolutegravir mg/l 1,53
Elvitegravir mg/l 1,04
Lopinavir mg/l 7,01  6,91 6,62 7,09
Nelfinavir mg/l 2,04
Rilpivirine mg/l 0,302  0,299 0,298
Ritonavir mg/l 5,02  4,93 4,95 5,05
Saquinavir mg/l 1,50 1,48 1,57 1,48
Antiretrovirals II
Amprenavir mg/l 2,06 1,97 1,93 2,01
Efavirenz mg/l 2,55  2,66 2,50 2,53
Etravirine mg/l 1,02 1,02 1,03 0,977
Nevirapine mg/l 3,87 3,85 4,02 4,00
Raltegravir mg/l 2,05 1,97 2,05 1,94
Tipranavir mg/l 15,16  14,76 15,72 14,81
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