Kwaliteitsbewaking Klinische Geneesmiddelanalyse en Toxicologie

Concentration tests and controls.

KKGT / Programma’s / Antischimmel middelen / Concentration tests and controls

strong>Concentration tests 2021

Components Unit Round 2021.1 Round 2021.2 Round 2021.3 Round 2021.4
Fluconazol mg/l  3,00  20,03 16,05 71,66
Flucytosine mg/l  126,6  9,49 63,35 6,28
Isavuconazol mg/l  0,155  7,76 3,89 10,29
Itraconazol mg/l 1,065  3,19 0,213 1,057
Hydroxy-Itraconazol mg/l 0,111  0,742  2,32 5,76
Posaconazol mg/l 7,00 10,49 0,315  1,74
Voriconazol mg/l  0.577  4,80  3,21  12,72

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strong>Concentration tests 2020

Components Unit Round 2020.1 Round 2020.2 Round 2020.3 Round 2020.4
Fluconazol mg/l  3,69  68,61 137,1 35,90
Flucytosine mg/l  94,93  113,0 9,41 59,15
Isavuconazol mg/l  0,191  7,57 10,08  2,64
Itraconazol mg/l 0,414  0,0877 6,84  8,96
Hydroxy-Itraconazol mg/l 0,876  0,1854  7,24 9,48
Posaconazol mg/l 0,0417 0,0827 4,13 6,49
Voriconazol mg/l  2,55  0,0809  10,1 13,22

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Concentration tests 2019

Components Unit Round 2019.1 Round 2019.2 Round 2019.3 Round 2019.4
Fluconazol mg/l  2,95  23,58  15,76 70,78
Flucytosine mg/l  117,5  11,02 58,93  7,35
Isavuconazol mg/l  0,227  7,57 3,79  11,36
Itraconazol mg/l  1,08  3,25 0,217  1,08
Hydroxy-Itraconazol mg/l  0,0936  0,750 2,35  5,86
Posaconazol mg/l  7,35 11,03 0,332  1,84
Voriconazol mg/l  0,658  5,49 3,67  14,64

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Concentration tests 2018

Components Unit Round 2018.1 Round 2018.2 Round 2018.3 Round 2018.4
Fluconazol mg/l  5,27  18,86 31,37  50,02
Flucytosine mg/l  10,88  36,34  43,52  150,6
Itraconazol mg/l  0,661  5,18  2,07  4,12
Hydroxy-Itraconazol mg/l  0,789  4,94  1,58  3,93
Posaconazol mg/l  0,953  1,27  0,305  3,17
Voriconazol mg/l  1,83  10,19  0  0,76

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Concentration tests 2017

Components Unit Round 2017.1 Round 2017.2 Round 2017.3 Round 2017.4
Fluconazol mg/l 10,13  25,26  3,01 40,32
Flucytosine mg/l 16,18  76,85  26,70  92,01
Itraconazol mg/l 0,942  1,88  1,12  5,63
Hydroxy-Itraconazol mg/l 0,387  1,93  1,44  3,86
Posaconazol mg/l 2,58  4,12  0,511  2,06
Voriconazol mg/l 0,193  3,23  1,20  5,37

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Concentration tests 2016

Components Unit Round 2016.1 Round 2016.2 Round 2016.3 Round 2016.4
Fluconazol mg/l  1,98  33,07 9,89  59,26
Flucytosine mg/l 11,54  72,20 28,78  119,8
Itraconazol mg/l 1,08 3,36 2,68  4,02
Hydroxy-Itraconazol mg/l 1,25  3,14  1,88  3,75
Posaconazol mg/l  0,394  1,32  0,295 3,27
Voriconazol mg/l 1,10 7,85  0,0986  0,821

Concentration tests 2015

Components Unit Round 2015.1 Round 2015.2 Round 2015.3 Round 2015.4
Fluconazol mg/l  2,98  16,58  6,56  19,87
Flucytosine mg/l  18,97  65,90  14,08  52,63
Itraconazol mg/l  0,507  4,22  0,835  5,27
Hydroxy-Itraconazol mg/l  0,551  3,06  1,09  3,82
Posaconazol mg/l  2,45  3,68  0,486  1,84
Voriconazol mg/l  8,75  13,13  0,303  4,37

Concentration control (matrix: liquid human serum)

Components Weighed-in value
Unit 2021 2020 2019 2018 2017 2016 15002 2015
Fluconazol mg/l  5,92 5,69 6,65 5,94 5,67 5,95 6,06 6,03
Flucytosine mg/l 58,41  58,60 62,13 63,85 57,54 60,41 58,78 59,95
Isavuconazol mg/l 2,87  2,94 3,20
Itraconazol mg/l  0,983  0,958  1,14 1,09 1,06 0,996 1,03 0,960
Hydroxy-Itraconazol mg/l  1,07  1,01  0,990 1,04 1,09 0,990 0,958 1,04
Posaconazol mg/l  1,94  2,01  2,33 2,15 1,93 1,98 2,01 1,95
Voriconazol mg/l  2,96  2,95  3,09 3,22 3,22 3,04 3,00 2,99

 

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