Kwaliteitsbewaking Klinische Geneesmiddelanalyse en Toxicologie

Concentration tests en controls.

Concentration tests 2017

Components Unit Round 2017.1 Round 2017.2 Round 2017.3 Round 2017.4
Benzodiazepinen I
Clobazam µg/l 340,3  57,19  205,1
Desmethylclobazam µg/l 2131  170,6  428,1
Clonazepam µg/l 30,79  55,00  15,46
Midazolam µg/l 270,7  541,6  679,8
Hydroxymidazolam µg/l 105,1  78,85  158,4
Benzodiazepinen II
Diazepam µg/l 429,5 863,7  172,6
Desmethyldiazepam µg/l 755,7  1520  303,7
Temazepam µg/l 159,3  400,4  53,4
Oxazepam µg/l 495,0  3318  994,7

Concentration tests 2016

Components Unit Round 2016.1 Round 2016.2 Round 2016.3 Round 2016.4
Clobazam µg/l  144,6  288 717,4 271,3
Desmethylclobazam µg/l 602* 942*  4790  2073
Clonazepam µg/l 43,11  107,3  23,96  53,92
Midazolam µg/l 228,3 1516  566,3  171,3
Hydroxymidazolam µg/l 88,06  292,3  116,5  41,12

* consensus waarde

Concentration tests 2015

Components Unit Round 2015.1 Round 2015.2 Round 2015.3 Round 2015.4
Clobazam µg/l 347,7 226,6  74,54  187,7
Desmethylclobazam µg/l 3684 4456  2199  2952
Clonazepam µg/l 28,44 15,92  78,57  47,48
Midazolam µg/l 187,0 75,37  531,3  802,6
Hydroxymidazolam µg/l 71,07 22,92  169,7  113,9

Concentration control (matrix: lyophilised bovine serum)

Components Weighed-in value
Unit 2017 2016 2015 2014
Clobazam µg/l 239,4  246,7 250,1 242,7
Desmethylclobazam µg/l 1499 1486 2459 2492
Clonazepam µg/l 38,68 39,24 39,54 39,16
Midazolam µg/l 238,1  259,7 222,8
Hydroxymidazolam µg/l 92,43  93,50 94,87
Diazepam µg/l 357,2  – 361,5
Desmethyldiazepam µg/l 196,4  – 393,2
Oxazepam µg/l 514,5  – 1621
Temazepam µg/l 103,5  – 493,5
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