Kwaliteitsbewaking Klinische Geneesmiddelanalyse en Toxicologie

Concentration tests and controls.

KKGT / Programma’s / Cardiaca / Concentration tests and controls

Concentration tests 2018

Components Unit Round 2018.1 Round 2018.2 Round 2018.3 Round 2018.4
Amiodaron* mg/l 1,50  0,79 2,26
Desethylamiodaron* mg/l  1,40  0,76 4,18
Coffeine mg/l 17,01  34,3 8,51
Digoxine µg/l 0,769  3,62  1,28
Flecainide mg/l  1,43  0,432 0,572
Theophylline mg/l 33,72  6,80 10,12

 

Concentration tests 2017

Components Unit Round 2017.1 Round 2017.2 Round 2017.3 Round 2017.4
Amiodaron* mg/l 1,49 0,30  0,86 1,92
Desethylamiodaron* mg/l 1,41 0,28  2,09  0,81
Coffeine mg/l 12,69  19,01  4,76  15,85
Digoxine µg/l 0,499 0,997  2,00  1,25
Flecainide mg/l 0,579 0,555  0,868  0,278
Theophylline mg/l 8,98 17,94  14,96  2,99

Concentration tests 2016

Components Unit Round 2016.1 Round 2016.2 Round 2016.3 Round 2016.4
Amiodaron* mg/l  1,49 3,72 0,92 1,85
Desethylamiodaron* mg/l 1,49 3,69 1,85 1,14
Coffeine mg/l 16,15 10,08 36,14 12,12
Digoxine µg/l 1,82 0,727 2,90  1.46
Flecainide mg/l 0,496 0,792 0,704  1,77
Theophylline mg/l 31,29 17,85 6,67  13,42

*Consensusvalues amiodaron and desethylamiodaron

Concentration tests 2015

Components Unit Round 2015.1 Round 2015.2 Round 2015.3 Round 2015.4
Amiodaron* mg/l 1,31 2,12  0,446  1,73
Desethylamiodaron* mg/l 1,21 0,424  1,65  2,04
Coffeine mg/l 14,59 18,62  5,31  8,33
Digoxine µg/l 1,20 0,496  2,04  1,00
Flecainide mg/l 0,616 0,510  0,838  0,308
Theophylline mg/l 17,29 3,81  11,75  9,60

*Consensusvalues amiodaron and desethylamiodaron

Concentration control (matrix: lyophilised bovine serum)

Components Weighed-in value
Unit 2018 2017 2016 2015 2014
Amiodaron* mg/l  1,42 1,44 1,45 1,48 1,40
Desethylamiodaron* mg/l  1,32 1,36 1,45 1,36 1,32
Coffeine mg/l 12,04 12,28 11,76 11,97 11,83
Digoxine µg/l 0,967 0,966 0,989 1,01 0,970
Flecainide mg/l 0,674 0,672 0,687 0,694 0,663
Theophylline mg/l 12,73 11,58 12,15 11,09 11,88

*Consensusvalues amiodaron and desethylamiodaron

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