Kwaliteitsbewaking Klinische Geneesmiddelanalyse en Toxicologie

Concentration tests and controls.

KKGT / Programma’s / Cardiaca / Concentration tests and controls

Concentration tests 2021

Components Unit Round 2021.1 Round 2021.2 Round 2021.3 Round 2021.4
Amiodaron* mg/l 1,48 2,12 0,38  1,02
Desethylamiodaron* mg/l 1,33 2,00 1,03  0,397
Coffeine mg/l 11,99  15,06 5,99  17,97
Digoxine µg/l 1,26  0,507  2,02  1,513
Flecainide mg/l 0,309  0,466 0,618  0,772
Theophylline mg/l 16,60  4,17  8,30  13,82

Concentration tests 2020

Components Unit Round 2020.1 Round 2020.2 Round 2020.3 Round 2020.4
Amiodaron* mg/l 1,55 0,78 3,04  1,91
Desethylamiodaron* mg/l 1,29 0,63 1,86 3,62
Coffeine mg/l 8,71 34,69 17,35  13,02
Digoxine µg/l 1,74 1,30  3,04 0,869
Flecainide mg/l 0,754  0,501 1,002 1,504
Theophylline mg/l 35,53 7,58 10,12 15,19

 

Concentration tests 2019

Components Unit Round 2019.1 Round 2019.2 Round 2019.3 Round 2019.4
Amiodaron* mg/l  1,48  2,18 0,363 1,09
Desethylamiodaron* mg/l  1,39  1,96  0,82  0,336
Coffeine mg/l  12,26 15,32  6,14  18,40
Digoxine µg/l 1,35  0,539  2,16 1,62
Flecainide mg/l 0,311  0,517  0,622 0,829
Theophylline mg/l 18,36  3,06  9,20 15,31

 

Concentration tests 2018

Components Unit Round 2018.1 Round 2018.2 Round 2018.3 Round 2018.4
Amiodaron* mg/l 1,50  0,79 2,26  3,72
Desethylamiodaron* mg/l  1,40  0,76 4,18  1,76
Coffeine mg/l 17,01  34,3 8,51  12,85
Digoxine µg/l 0,769  3,62  1,28  1,55
Flecainide mg/l  1,43  0,432 0,572  0,863
Theophylline mg/l 33,72  6,80 10,12  16,98

 

Concentration tests 2017

Components Unit Round 2017.1 Round 2017.2 Round 2017.3 Round 2017.4
Amiodaron* mg/l 1,49 0,30  0,86 1,92
Desethylamiodaron* mg/l 1,41 0,28  2,09  0,81
Coffeine mg/l 12,69  19,01  4,76  15,85
Digoxine µg/l 0,499 0,997  2,00  1,25
Flecainide mg/l 0,579 0,555  0,868  0,278
Theophylline mg/l 8,98 17,94  14,96  2,99

Concentration tests 2016

Components Unit Round 2016.1 Round 2016.2 Round 2016.3 Round 2016.4
Amiodaron* mg/l  1,49 3,72 0,92 1,85
Desethylamiodaron* mg/l 1,49 3,69 1,85 1,14
Coffeine mg/l 16,15 10,08 36,14 12,12
Digoxine µg/l 1,82 0,727 2,90  1.46
Flecainide mg/l 0,496 0,792 0,704  1,77
Theophylline mg/l 31,29 17,85 6,67  13,42

*Consensusvalues amiodaron and desethylamiodaron

Concentration tests 2015

Components Unit Round 2015.1 Round 2015.2 Round 2015.3 Round 2015.4
Amiodaron* mg/l 1,31 2,12  0,446  1,73
Desethylamiodaron* mg/l 1,21 0,424  1,65  2,04
Coffeine mg/l 14,59 18,62  5,31  8,33
Digoxine µg/l 1,20 0,496  2,04  1,00
Flecainide mg/l 0,616 0,510  0,838  0,308
Theophylline mg/l 17,29 3,81  11,75  9,60

*Consensusvalues amiodaron and desethylamiodaron

Concentration control (matrix: lyophilised bovine serum)

Components Weighed-in value
Unit 2021 2020 2019 2018 2017 2016 2015
Amiodaron* mg/l  1,43 1,45  1,47 1,42 1,44 1,45 1,48
Desethylamiodaron*1,36 mg/l 1,35 1,35  1,37 1,32 1,36 1,45 1,36
Coffeine mg/l 12,17 12,19 12,08 12,04 12,28 11,76 11,97
Digoxine µg/l  1,02 1,02 1,06 0,967 0,966 0,989 1,01
Flecainide mg/l 0,717 0,704 0,680 0,674 0,672 0,687 0,694
Theophylline mg/l  12,03 11,85 12,06 12,73 11,58 12,15 11,09

*Consensusvalues amiodaron and desethylamiodaron

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